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In each case the action of adrenaline is identical with thatof stimulation of the hypogastric nerves which carry both motor andinhibitory fibres to the uterus; the relative power of the two sets offibres varies in different animals and in different conditions in the sameway as the action of adrenaline (fig.the eye. The first consists of an increase in the cheapest generic ultram online legitimate force of contraction due to direct stimulation of the cardiac muscle, usuallygroup of digitoxin. This is shown by thefact that it acts much more quickly and in smaller doses when it isapomorphine 435injected hypodermically buy drug ultram 200mg in japan or intramuscularly than when it is swallowed,and also buy drug ultram 200mg in japan by the fact that if the medulla buy drug ultram 200mg in japan be brushed with apomorphinesolution, vomiting follows immediately. Even the largest quantities, however,are followed by no symptoms except those of gastrointestinal irritationand inflammation, and the longcontinued use of alum does not ehritany symptoms of chronic poisoning. When injected subcutaneously or intravenouslyinto animals, bile or bile salts produce a depression of the heartand central nervous system and decompose the red blood corpuscles. 28 the time is in hours to show the gradualrecovery. Among thesemay ultram 200mg prescription how to write be mentioned the salicylate and benzoate, which have been used asintestinal antiseptics and astringents. Hrvatski PR stručnjaci moraju težiti da budu dirktno povezani s donositeljima odluka unutar svojih organizacija. It is administered subcutaneously every few days.its action lasts for several days.other buy drug ultram 200mg in japan animal extracts. As a matter of fact the temperature is notreduced in malaria by action on the tissuesbut by destruction of theparasite which causes the rise in temperature; and until this is accora-plished, quinine is unable to reduce the body cheapest generic tramadol 50mg online no prescription heat or even to preventits rising. Of iron three times a day, about thirtytimes as much iron is given as is required normally in food, so thatthe chlorotic receives more iron per day than a workman in a where to purchase ultram 100mg in the uk online month.iron is buy generic lorazepam 2mg online legitimate occasionally injected hypodermically, with the buy drug ultram 200mg in japan object ofavoiding the irritation of the stomach, but this procedure is painfuland causes some swelling and irritation, which lasts twentyfour houtfiron tramadol non prescription 647or more. Depression and weakness,ataxia and clonic convulsions follow on larger doses, which provefatal by paralyzing the respiratory centre. The third, and sometimes the most important parameter forevaluation, is the area under the serum, blood, or plasma con-centration–time curve (auc). Patientsshould be counseled that concomitant use ofwith nitrates could cause blood pressure to suddenly drop to an unsafe level,resulting in dizziness, syncope, oreven heart attack or stroke.physicians should inform their patients thatin some patients concomitant use buy drug ultram 200mg in japan of pde5inhibitors, including with alpha-blockers can lower blood pressure significantlyleading to symptomatic hypotension (e. — aconite is employed to some extent to slow thepulse and reduce the temperature in fever. Since the molecular environment of the protons can producecharacteristic shifts in the proton nmr spectrum, nmr is a powerful tool inthe identification of molecules in medicinal chemistry and chemical develop-ment. Properly, otherwise you may not get the results youa?re looking for. Dysfunction - ed erectile dysfunction (ed) is the inability of a man to achieve or maintain an erection sufficient for his or his partner's sexual needs. They are of the three varieties proteolytic, amylopsic and steapsic: under these circmnstances, thecirculation may, at tramadol websites times, be restored by violently compressingthe thorax high off tramadol with the object of squeezing out the poisonous bloodfrom the heart and mechanically stimulating this organ.the blood is imdoubtedly affected by ether, as the red bloodcorpuscles become destroyed. Dy spepsia , buy drug ultram 200mg in japan want of appetite, andconsequent loss of flesh may also be explained by the local frritationproduced byfchd-nicotine swallowed in the saliva. A great deal of weight was formerly laidon the use of purgatives and emetics as preliminaries to the treat-ment of malaria with quinine, and the former are undoubtedly ofservice sometimes, although it is unnecessary to delay the quininetreatment by waiting for the intestines to be evacuated.quinine is used not only as a remedy, but also as a prophylacticagainst malaria. In such cases, a clinicalresponse to empiric therapy may be an important clue to buy drug ultram 200mg in japan thelikely pathogen.frequently, the signs and symptoms of infection diminish as aresult of empiric therapy, and microbiologic test results becomeavailable that establish a specific microbiologic diagnosis. Humanizing the discourse surrounding erectile dysfunction. 32). In general terms, those compounds in which one hydrogen atom issubstituted, tend to cause greater nervous stimulation than buy drug ultram 200mg in japan those in which twoor three such substitutions are made, while this action is again more promi-nent in those in which four alkyl groups are combined with the nitrogen. Because ritonavir prolongselimination half-life (5to 6-fold), no more than a single 2.5 mg dose ofshould be taken in a 72-hour period by patients alsotaking ritonavir. Irritation of thestomach, or hyperacidity of the gastric juice, is, of course, a contra-indication.acid may also be used to make the urine acid, and thus to render itless favorable to the growth of microbes. Penile reflexes in rats after different numbers of ejaculations. Thedifferent buy drug ultram 200mg in japan glucosides differ in the duration of their action; thus hatcherestimates that seven-eighths of the strophanthin in the tissues iseliminated within twenty-four buy drug ultram 200mg in japan hours, while half the principles of digitalisremain active buy drug ultram 200mg in japan buy drug ultram 200mg in japan after four days. The worldlevels of resistance to cip have been relatively low, reaching 2.4% inteheran/iran 27 , 5.7% in chile 23 , 7.9% in spain 28 and 9.5% in germany 12 .similarly, the data of this study also revealed a reduced rate of h. They defined 1.0 mac as the partial pressureof an inhalational anesthetic in the alveoli of the lungs at which50% of a population of nonrelaxed patients remained immobileat the time of a skin incision. Several plants which contain glucosides similar to amygdalinhave given rise to poisoning in cattle, buy drug ultram 200mg in japan probably from prussic acid beingfreed from the glucosides buy drug ultram 200mg in japan in the intestine.prussic acid and its salts have practically the same action, althoughnone of the latter are so poisonous as the free acid. The blood contains a much smalleramount of oxygen than normally, in some cases only 1 per cent, instead of17, and artificial respiration or even shaking the blood in air fails to oxidize itfurther, as the combination of rafrrjhcnzpl and hflpmflflnhin nmrrn to be incapableof absorbing oxygen. The basis of many of the plastersis lead plaster, which is obtained by the action of lead oxide on olive buy drug ultram 200mg in japan oil andconsists for the most part of lead oleate.court plaster is formed from isinglass, the dried swimming bladder of severalspecies of sturgeon, which is dissolved in water, alcohol and glycerin and paintedon taffeta. Specifications, production formulas and instructions, batchrecords and procedures must be without error and available for inspection.productionthe manufacturing of a drug must be carried out in accordance with clearlydescribed procedures. — 12 tablets.sodii nitris (u.) (nanoj) white crystalline body, soluble inwater. Buy,, online for the effective treatment of impotence, erectile dysfunction. As thecomposition of glass may be varied by the amounts and types ofsand and silica added and the heat treatment conditions buy drug ultram with paypal used,the proper container for any buy drug ultram 200mg in japan formulation can be selected.according to usp 34, glass containers suitable for packagingpharmacopeial preparations may be classified as either type i,type ii, type iii, or type np. I am considering getting a hair transplant and i buy drug ultram 200mg in japan had a few questions. Otherwise, some provisions aredescribed in cases of non-compliance with the study protocol, gcp, regula-tions, premature termination or suspension of a trial or multicentre studies.clinical trial protocolbesides general administrative information such as study title, sponsor, inves-tigator sites, the background information about want to buy ultram 50mg in the uk online the drug product and the trialobjectives and purpose, a clinical study protocol includes the following topics:- trial design: in this disease, besidesthe toxic action on the heart, there may be present more or less obstruc-tion of the pulmonary vessels through pressure, resulting in overworkand dilatation of the right heart. Inhibition of apomorphine-induced yawning and penile erection by neurotensin. In some cases no lesion of the canal is observed post mortem,but in the great majority congestion and swelling of the mucous mem-branes of the stomach and intestine is seen, or the whole surface may becovered by a diphtheritic buy drug ultram 200mg in japan membrane composed of necrosed cells andinflammatory exudate. Buy drug ultram 200mg in japan benzoic add is where to buy tramadol 200mg tablets online uk excreted, partly as such, buy drug ultram 200mg in japan partlycombined with glycocou in the form of hippuric acid, by the urinewhere it acts as an antiseptic and irritant. Dexmedetomidine is a highly selective (x 2 -adrenergic agonist.recognition of the usefulness of 0t 2 agonists is based on observa-tions of decreased anesthetic requirements in patients receivingchronic clonidine therapy. buy lorazepam 2mg online no prescription roller mills have two ormore rollers that revolve at different buy drug ultram 200mg in japan speeds, and the buy drug ultram 200mg in japan particlesare reduced to a mesh of 20–200 by means of compression anda shearing action.ailed discussion on particle size reduction of solids.)in the pharmacy, ceramicmortar and pestle are better atgrinding and reducing particle size than glass. Otherssuppose buy drug ultram 200mg in japan that the liver buy drug ultram 200mg in japan retains and destroys it, and a third view is thatit is rendered innocuous in passing through the stomach walls.the characteristic action of curara on the myoneural junction instriated muscle is antagonized to some extent by pbysostigmine ,nirvvh'np, ftpd snm nthpr alkaloids.curine, the second alkaloid found by boehm in some specimens of curara,is a much less poisonous body than curarine. The recommended test for such stud-ies is the determination of tablet friability as described in theusp.

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Dna repair, chromosome damage). Thus in framboesia buy drug ultram 200mg in japan (yaws),recurrent fever, and vincent's angina, it is buy drug ultram 200mg in japan remarkably efficient, and inspirillosis of the lower animals an equal success has followed its use.in malaria salvarsan is inferior to quinine, and in sleeping sickness itappears to be less useful tramadol prescription san diego than atoxyl. The psychometric properties of the penile tumescence assessment of child molesters. On the other hand, it increases thesusceptibility of rats to want to buy ultram 50mg in canada the same poison, and morphine is more toxicto both purchase generic tramadol 100mg tablets online mice and rats when they have been treated with thyroid forsome time previously. Some formsof intermission of the pulse are due to unusual activity of the inhibitoryapparatus, and these may be remedied by atropine; but this inter-mission possesses little importance, and seems to require no therapeutictreatment. The alcoholic, lactic andbutyric fermentations are retarded, or entirely prevented by quininethrough its effects on the organisms, but it is apparently devoid ofaction on some of the lower forms, for moulds (penicillium) growfreely in solutions tramadol 100mg prescription symptoms of the salts; so that the alkaloid seems to have aselective action here, such as is observed also in its effects on the fer-ments of the higher animals. It is sometimes of service in painful or itching skin diseases, butcare must be taken not to apply it to large broken surfaces, otherwisesymptoms of poisoning may follow. Second, adjunc-tive drugs that act through different receptor mechanisms andproduce different toxicides may allow lowering the dose of thefirst drug, thus limiting its toxicity (eg, use of other immunosup-pressive agents added buy drug ultram 200mg in japan maximum tramadol dosage to glucocorticoids in treating inflammatorydisorders). Inordinary circumstances, therefore, they have no need to protect thefixed alkalies, and are unprovided with any mechanism for this purpose.when an excess of acid is absorbed, they neutralize it by means of thefixed alkali of the tissues and blood, and thus lessen the available alkaliof buy drug ultram 200mg in japan the blood, which becomes unable to carry so much carbonic acidfrom the tissues to the lungs. It is often added to milk in intestinal irritation in childrenand in typhoid fever, as it is found that milk thus treated coagulatesin finer particles than when given alone, and is better digested and lessliable to disturb the intestine. Many pharmaceutical companies are large multinationals thatoperate worldwide. (1560 it)0.) , 2.linimentum ammoniae (u.), contains about 3 per cent, ammonia. This change in color does not appear to impair its activityappreciably. Central nervous systembut secondarily afected and action on these parts of but utile importance in poisoning.— the indication par excellence for the use of the heart tonics is in conditions where theheart is accomplishing an insufficient work and where the bloodpressure is too low, and the arteries improperly filled. Men are already reluctant to talk about their own impotence issues because impotence and erectile dysfunction represent a challenge to male and masculine identity. Actually started out in studies as a medication to reduce blood pressure. In such cases it acts by depressing the motor nerveendings of the smooth muscles and even the muscle fibres themselves, thus relieving the spasm.it is used to relieve spasmodic contraction of other organs,such as that of the ureter, bladder, gall bladder, bile ducts andurethra, in cases alprazolam online of stones or other conditions in these organs producing spasm. And in many others, in which the symptoms showno signs of abating under hygienic measures, mercury causes a rapidand permanent improvement. Pulmonary disease may also affect drug metabolism, as indi-cated by the impaired hydrolysis of procainamide and procaine inpatients with chronic respiratory insufficiency and the increasedhalf-life of antipyrine (a p450 functional probe) in patients withlung cancer. It buy drug ultram 200mg in japan has also been shown (alwens) that when the tricuspidvalves of the heart have been injured in animals, they can be poisonedby smaller quantities of salvarsan than usual, and this has been attributedto the buy drug ultram 200mg in japan drug acting more strongly on the congested abdominal organs,especially the liver. Thereis a general buy drug ultram 200mg in japan consensus of opinion that the old treatment of malignanttumors, such as cancer and sarcoma, with iodides is hopeless. A more mechanism-based drug design buy drug ultram 200mg in japan is targeted syn-thesis, where researchers focus on one step in a disease pro-cess as the target for drug intervention. Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in thecorpus cavernosum and its associated arterioles. When failure of respiration occurs from an overdose ofether, it may be overcome by stopping the administration of this when pure nitrous oxide is inhaled without admixture ofair, the patient passes rapidly through the s3nnptoms just described, then becomes unconscious, and cheapest generic ultram after deep cyanosis,dyspnoeic and stertorous breathing, the respirations cease beforethe circulation.nitrous buy drug ultram 200mg in japan oxide imdiluted with air, produces atuesthesia somewhatsimilar to that obtained by ether. It has buy drug ultram 200mg in japan been employed instead ofpepsin or pancreatin buy drug ultram 200mg in japan to help gastric or pancreatic digestion. It is sometimes mixed with flour or driaigypsum purchase ultram colorado springs and water to a paste (canquoin's paste), when a less active causticis where to buy tramadol 200mg tablets online uk desired. Full characterization includes physicaland chemical stability. buy drug ultram 200mg in japan on the other hand, the calcium salts themselves arepoisonous when they buy drug ultram 200mg in japan are buy drug ultram 200mg in japan not counterbalanced by sodium and potassium; in this,as in many other instances, there must be maintained between the inorganicconstituents of the surrounding fluid an equilibrium, such as exists in sea waterin the case of the fundulus, and in the blood plasma in the case of the heart andother organs.the salts of buy drug ultram 200mg in japan the alkaline earths are said to inhibit the hemolytic action ofcertain serums, while those of the alkalies have not this effect when applied inthe same concentration; this may perhaps be connected with the tendency theformer have to coagulate proteins. It seldom produces much griping or pain.this action, however, only applies to the expressed oil, for thecastor beans themselves are very toxic; one has produced fatalpoisoning, which consists of exceedingly severe gastroenteritiswith excrudating pains in the abdomen, nausea, vomiting,cyanosis, failure of the heart and respiration, and death in collapse. Placebo. Not yet a member? All together, these measures contributed to theincreasingly global nature of drug development.despite all these efforts buy drug ultram 200mg in japan for worldwide regulatory convergence that shouldmake life easier for drug development organisations, there is still a lot ofdisparity, variance or disagreement between regions and countries whenit comes to certain issues related to drug development and approval. When the latter buy drug ultram 200mg in japan has once set in, ergot isof less immediate service, as it is slowly absorbed, and no effects followfor some twenty minutes or more. For cuti and aup, where 1000 mg is the appropriate dose, the dosage of cipro xr should be reduced to cipro xr 500 mg q24h buy drug ultram 200mg in japan in patients with creatinine clearance want to buy ultram online europe equal to or below 30 ml/min [see dosage and administration]. A change of treatment from propecia to placebo (n=48) purchase tramadol minnesota at the end of the initial 12months resulted in reversal of the increase in hair count 12 months later, at 24 months (see figurebelow).at 12 months, 58% of men in the placebo group had further hair loss (defined as any decrease in haircount from baseline), compared with 14% of mentreated with propecia. In thelower animals, it increases the reflex irritability of the cord verymarkedly, and produces, in sufficient doses, convulsions of eitherclonic or tetanic character. Aconitine isthe most poisonous of the alkaloids, 0.2 mg.) taken by themouth inducing distinct symptoms in man, and its use buy drug ultram 200mg in japan in ointment orsolution must be guarded. Drugs containing esters (e., cocaine, physostigmine, aspirin,tetracaine, procaine, and methyldopa), amides (e., dibu-caine), imides (e., amobarbital), imines (e., diazepam), andlactam (e., penicillins, cephalosporins) functional groups areamong those prone to hydrolysis.hydrolysis reactions buy drug ultram 200mg in japan are often ph dependent and are cata-lyzed by either hydronium ion or hydroxide ions (specific-acidor specific-base catalysis, respectively). When a drug isused in suitable doses to produce beneficial influences, it is saidto be a medicine. When mild vasodilators are taken in combination, blood-pressure-lowering effects of each individual compound may be increased. Glycine has beeen suggested for the same reason as the sul-phates in phenol poisoning, but would presumably be of no greatervalue.methyl salicylate, or oil of wintergreen, is often applied locally inmuscular and articular rheumatism, it being supposed that largerquantities thus reach the focus of disease than when the drug is takenby the mouth. There buy drug ultram 200mg in japan have been rare cases reported where the possibility of such an interaction could not be entirely excluded; however there was no specific evidence that such an interaction had occurred.theophylline: You may well find yourself being buy drug ultram 200mg in japan given short notice for interview after submitting applications so it is crucial to stay up-to-date.

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Novel actions, deleterious effects, and clinical potential (pp. Usually it lasts about one day, althoughit may be present several days. Or are often the first treatment tried for erectile dysfunction. Laboratory data management for the collection and integration of dataproduced in safety pharmacology and toxicology studies. Some women expect their mates to magically understand what they want and need. Used externally as anantiseptic dusting powder. In buy drug ultram 50mg in singapore addition to compound collections, organic chemists andbiochemists derive leads from where to purchase clonazepam online no prescription natural product sources. The stomach is seldom affected, the appetite gener-ally remaining good, but in some persons buy drug ultram 200mg in japan iodides induce nausea andgastric discomfort. The type andnumber of initial screening tests depend on the pharmacologicand therapeutic goal. Information, you are able to find updated and useful information described in a very brief and easy to understand manner. Whenhypotonic solutions pass into the blood from the bowel, the proportionof solids and liquid is of course changed buy drug ultram 200mg in japan and fewer corpuscles and lesssolid matter are found in the cubic millimeter than normally buy drug ultram 200mg in japan (hydne-mia). Medical follow-up information was often limited for the cases reported postmarketing, which makes it difficult to determine whether these reports are directly related to the use of one of these drugs, an underlying medical condition, or other risk factors for hearing loss, a combination of these factors, or other factors. Oil of wintergreen may also be used here, but,like salicylic acid, is more liable to cause gastrkirritation. Biostatistics for the interpretation of safety pharmacology and toxicitystudies. The blood pressure atfirst rises on account of a combination of circumstances as follows:firstly, the tremendous stimulation and increase in the strengthof the cardiac muscles, secondly, the squeezing out of the bloodfrom the vessels of the splanchnic area due to the cordlike contraction of the intestines, and lastly, the primary stimulation ofthe vasomotor centre. The key clinical features include cheap pain medication online retinal degeneration (nystagmus, pathologic; retinitis pigmentosa; and eventual blindness), childhood obesity, sensorineural hearing loss, and normal mental development. Stabilizing factors include the presence of electrical charges at theparticle surface and the presence of adsorbed macromoleculesor nonionic surfactants. Dexmedetomidine is theactive a-enantiomer of medetomidine, a highly buy drug ultram 200mg in japan selective a 2 -adrenergic agonist imidazole derivative that is used in veterinarymedicine. It derives its name want to buy ultram 50mg in the uk online of carron oil fromhaving been used for this purpose in the iron works at carron.acreta prceparata (u.), prepared chalk, chalk purified by washingand suspension in water (cacoi).pulvis caetie compositus (u.), a mixture of prepared chalk, sugarand acacia.) pulvis cret\e aromaticus (b.), aromatic chalk powder, contains chalkalong with sugar and a buy drug ultram 200mg in japan number of carminatives belonging to the group ofvolatile oils. Both arsenicand iron may be advisable in some anaemias. It does not buy tramadol india paralyzethe nerve buy drug ultram 200mg in japan terminations of the salivary glands, nor those of thegastrointestinal tract, nor does it paralyze the nerve endings oforgans with smooth muscle fibres, nor the inhibitory apparatusof the vagus.it is a very powerful local irritant which may produce abscessby subcutaneous injection, nausea, vomiting and diarrhoea afterinternal administration, and sneezing after snuffing. buy drug ultram 200mg in japan itcolors the latter a deep brown, a stain which can be removedby benzine.resorciney another phenol, dioxybenzol, acts on warmblooded animals buy generic tramadol 100mg online with prescription very much like carbolic acid but less powerfully.it is, however, even more strongly antiseptic. Erectile function in two-kidney, one-clip hypertensive rats is maintained by a potential increase in nitric oxide production. Although an extensiveknowledge of the disease state is required, this more directedapproach increases the likelihood of successfully identifying alead compound. As with buy drug ultram 200mg in japan erythromycin and other macrolides, rare buy drug ultram 200mg in japan serious allergic reactions, including angioedema and anaphylaxis (rarely fatal), have been reported. — both the acid and its sodium salt irritate the mucous membranesand wounded surfaces, and cause inflammation and even suppuration wheninjected subcutaneously. Gaethgens asserts that the diaphragm, and eventually the otherstriated muscles are paralyzed soon afterward. In effect, the patient returns to the level of balding where he would have been had he never used the drug in the first place. The treatment is continued for a fortnight or three weeks. The anaesthetics and hypnotics do not differ markedly from eachother in their quality of action, but only in their clinical application on account buy drug ultram 200mg in japan of buy drug ultram 50mg with american express their difference purchase generic tramadol in florida in physical properties. The findings give riseto 'corrective and preventive actions' or 'capa' in order to preventfuture errors. Its salts were usedinternally as antipyretics, but were afterwards discarded because of theirdanger. We heard about what works and buy drug ultram 200mg in japan what challenges they face. Buy drug ultram 200mg in japan when the buy drug ultram 200mg in japan drug development process iscompleted, a dossier is prepared to apply for a marketing authorisation of thedrug. Chris lipinski of pfizer and have become known as buy drug ultram 200mg in japan the“lipinski rule of five.” based on his analysis of drugs devel-oped predominantly at pfizer, dr. If bismuth is prescribed with alkalies, the carbonate buy drug ultram 200mg in japan should be used, as the subnitrate is slightly acid in reaction.the subnitrate has been advised buy drug ultram 200mg in japan in surgery as an antiseptic, astringent powder to replace iodoform. It can help men with ed get and keep an erection satisfactory for sexual activity. Because suspended drug must undergo a dissolutionstep prior to crossing biological membranes, suspensions offera way to provide sustained release of drug by parenteral, topical, and oral routes of administration. what are phentermine during the market life of anew drug its use is continuously monitored to detect side effects to improveits safe use in clinical practice. buy generic ultram 50mg with mastercard this is probably due to the iodine contained, and not to thespecific gland secretion. In this phase of drug discovery more advanced in vivo screening systemsare introduced to refine the selection process. It is muchmore poisonous than ethyl alcohol, and this is probably becauseit is buy drug ultram 200mg in japan oxidized to formic add and formic aldehyde, which arethemselves poisonous. If you have been using propecia since age 24, that suggests that you could lose a tremendous amount of hair over a year or two period if you stopped taking propecia. Although other risk factorswere present in some cases (such as age, diabetes, hypertension and previous hearing loss history).nitratesin clinical studies, tadalafil (5, 10 and 20 mg) was shown to augment the hypotensive effects ofnitrates. So men use all sorts of stratagems to deal with the problem - making excuses, pretending it does not bother them, avoiding intimacy. Pills with all orders, fast secure & anonymous worldwide delivery.

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