Buy cheap xanax online in usa - Save up to 90%

October 5, 2020 7:31 pm Published by Leave your thoughts


Buy cheap xanax online in usa
97% like it View all 1602 reviews $0.29 - $2.87 per pill

order alprazolam minneapolis


For example, the contribution of clinical development increases substantially upon buy cheap xanax online in usa transferring a drug candidatefrom early development into late development when the major clinical trialstake place. buy cheap xanax online in usa order alprazolam online legitimate hair counts were obtained in the anteriormid-scalp area, and did not include the area of buy cheap xanax online in usa bitemporal recession or the anterior hairline.summary of clinical studies in menclinical studies were conducted in men aged 18 to41 with mild to moderate degrees of androgeneticalopecia. During life the urine presents the ordinary appearancesof this disease, being copious in amount and of low specific gravity,and containing where to buy alprazolam 1mg no prescription comparatively small quantities of albumin or casts.in some cases in man, the kidney has presented a mixture of parenchymatous and interstitial disease, while in animals the parenchymaalone is affected, perhaps because the experiments have not lasted longenough. And mercuryadministered by the mouth is in all cases more liable to derange thedigestion than when administered by other channels, and on the wholeis buy cheap xanax online in usa less certain and less satisfactory in its results.inunction was introduced to avoid the disturbance of the stomachand intestine caused by the local action of the mercury, while that dueto its excretion along the alimentary tract remained unchanged. The buy generic xanax 1mg online europe fall of blood pressure and buy cheap xanax online in usa failure of circulationwhich soon ensue are due to direct paralysis of the heart and ofthe vasomotor centres.the local application of cocaine causes a powerful contractionof the buy cheap xanax online in usa blood vessels, which produces in the nose a shrinking ofthe turbinates, in the throat and other mucous membranes ablanching and dryness of the mucosa, and in the eye a decreasein the intraocular tension. The study included a number of 55children with voiding dysfunction symptoms. It is statedthat when iodide is given along with mercury, the buy cheap xanax online in usa latter does notaccumulate in the liver, but the statement requires confirmation.finally, iodide of potassium is sometimes added to other drugs incases of malingering, or in which buy cheap xanax online in usa it is suspected that the patient isnot takifig the remedy as directed. Eortc.be), the buy cheap xanax online in usa drugs for neglected diseases initiative. It is in great measure oxidizedin the body, although a smaller portion is excreted in the urine.hyoscyamine resembles atropine very closely in buy xanax in ireland its action.it differs from the latter, as it usually depresses the cerebrum fromthe alprazolam discover card beginning and thus produces sleep, without an initial stage ofexcitement.scopolamine or hyosdne, acts very much like atropine, order alprazolam 1mg tablets except buy cheap xanax online in usa that it is still more depressant to the cerebrum than hyoscyamine. A number of other ferments act morevigorously in very dilute solutions of quinine, while they are retardedby larger quantities; for example, the autolytic ferment of the liver,pepsin, and rennet. And ergotoxine, while stimulating the'motor myoneural junctions in small doses, paralyzes them in largeramounts. A solution of 25 per cent,may also be applied to cauterize chancres and indolent ulcers, and oneof 12 per cent, may be buy cheap xanax online in usa painted on mucous membranes as an irritantdisinfectant; a solution of common salt is then used to wash the part,the heavy metalsin order to remove the excess of silver. Study a was conducted primarily in academic centers. Is less efficacious inblack as opposed to white people, or has specific side xanax 1mg prescription drug effects in asians asopposed to caucasians) and to suggest how to control these different effects(e. Patientsshould be advised of the possible occurrence of symptoms related to postural hypotension andappropriate countermeasures. Very small quantities suffice to causealarming or even fatal collapse in man and some animals, while inothers (e., the guinea-pig) the second injection proves fatal by im-mediate constriction of the bronchioles, which leads to asphyxia. Stimulation of the protoplasm ofthe salivary, lachrymal and sweat glands produces an increasein their secretions.8o constitutional organic drugs.the central nervous system, after a very brief stage of primary stimulation, is powerfully depressed, especially the centresin the medulla. The frog's heart is less easilyaffected than that of the mammals, but similar changes have beenobserved.the action on the heart may be demonstrated by perfusing verydilute solutions of adrenaline through the vessels of the excised heart,and the same method is used in investigating its action on the order alprazolam 1mg online in canada vesselsof buy cheap xanax online in usa other organs. Hiv-1 viral replication, immunodeficiency and genetic factors also contribute to kidney disease. Dorsal vein injuries observed during penile exploration for suspected penile fracture. This change in color does not where can i buy valium online appear to impair its activityappreciably. In such cases the patient should beprepared for the injection as if for an operation and should not beallowed to resume his ordinary occupation for several days; and thedoses should be reduced in buy cheap xanax online in usa amount.a large number of important drugs belonging to the chemicalseries of heavy metals resemble order xanax kansas city each other so closely in their action inliving organisms that they may be readily grouped together in a division of the pharmacological system. In this chapter some insight is offered into the drug discoveryprocess. They may even sell the data to hospitals and doctors.online buy cheap xanax online in usa pharmacies provide rebates and commissions to doctors to provide prescriptions on the basis of online informationthat has been filled by the patient. You should discuss the use of grapefruit and grapefruit juice with your doctor. In each case, there is interest cheap alprazolam pills in the complexrelationships between chemical structure and pharmacologicalaction. These are generally given alone in cases of buy xanax detection in drink heart disease,and it is of importance to remember that they do not maintain theirpower if they are kept, diluted with water. D\ outline of the heart in stand-still after digitalis; the ventricle, v, is fully contracted, while the auricles are dilated.(after sluytermann.) the action on the frog's heart is a direct one on the muscle; theinhibitory mechanism has nothing to do with the change "in the con-duction or with that in buy cheap xanax online in usa the contractility, for the application of atropinehas no effect upon either feature. They contain in thenative i per cent., in the cultivated 5 per cent, alkaloids. Such cases occur after the accidental ingestion of toadstools instead of edible mushrooms.the basis of the treatment consists of the administration 6f thealmost exact antidote, atropine, imtil the symptoms improve, inwashing out the stomach, and administering a purge to removethe remaining mushrooms.muscarine is a strongly alkaline deliquescent alkaloid, very soluble inwater, found in the fly mushrooms, agaricus muscarius. It has thereforebeen suggested that the glycogen is broken up with the formation oflactic acid owing to a specific action of phosphorus on the liver cells.in the kidney, the fatty degeneration of the epithelium may accountfor the albuminuria, which is not generally severe, and is not infre-quently absent in cases of poisoning. This suppression lasts4-8 hours after an buy cheap xanax online in usa induction dose of the drug. Early studies would bedone to predict effects that might later cause undesired drugmetabolism or toxicologic complications. Parenteral suspensions shouldalso be deflocculated to prevent the larger particles from clogging hypodermic syringes, causing tissue irritation, or blocking capillary blood vessels. Soon after the injectionthe animal shows symptoms of great restlessness and excitement; itseems unable to keep still, the dog at first showing all the signs buy cheap xanax online in usa ofaffection and excitement which he displays on ordinary occasions onbeing unchained or taken for a walk, but afterward want to buy diazepam 5mg in china running contin-ually in a circle and paying but little heed to anything around him.still later regular convulsions occur, and these are at first clonic, butmay afterward become tonic, and then resemble those seen in strych-nine poisoning. The movements of protoplasm in plants are alsoretarded or entirely suppressed by this poison, and the process of putre-faction is delayed buy cheap xanax online in usa considerably. It has very rarely been examined,except in an impure form, and the symptoms are imperfectly known.antimonii et potassii tartras (u.), antimonium tartaratum(b.), tartar emetic, tartrated antimony ( (ksbocih) + hio), formscolorless transparent crystals, or a white granulated powder, without odor,and having a sweet, afterward disagreeable, metallic taste, soluble in 17 partsof cold water, insoluble in alcohol. On the other hand if the plasma be titrated withan acid, more is required after an alkali has been administered, providedthe carbonic acid is driven off during the titration. The presence of these abnormal products in thissecretion and the destruction of glycogen in the muscles and liver,are probably due to asphyxia. Atight containerprotects the contentsfrom contamination by extraneous materials, loss of contents,efflorescence, deliquescence, or evaporation and how to buy alprazolam online is capable oftight re-closure. This is accomplished using an arrheniusplot to predict, from high-temperature data, the rate of productbreakdown to be expected at actual lower buy cheap xanax online in usa temperature storageconditions. In the course of a few hours. It is the ideal emetic. Recovery hasbeen observed after very large quantities, while in other cases 0.(2 grs.chronic antimonial poisoning is very rare and difficult to diagnose. Fatty foods will reduce absorption of the medication into the body. —0.005 g.benzylmorphine or peronin.cannabis indica (u.), flowering tops of cannabis sativa, buy cheap xanax online in usa indianhemp, a buy cheap xanax online in usa plant growing in hindustan and used by the natives as an intoxicantimder the name of haschisch or gunjah. More specifically, drug efficacy refers to the ability of a new drug buy cheap xanax online in usa to domore good than harm whenadministered to patients in a welldefined, homogeneous target population.during the many years that it takes to develop a drug, numerous scientificdata are generated, collected and reported in documents in buy cheap xanax online in usa what are called buy cheap xanax online in usa regulatory dossiers. The action must therefore belocalized at some point between the ganglia and the actual contractilesubstance, for the latter maintains its normal character respondingwith a contraction to stimuli. Being under stress can prevent you from focusing your mind on having sex. The buy cheap xanax online in usa respirations,at first hurried and deepened, afterwards become shallow andless frequent until they stop entirely, with almost simultaneousarrest of the circulation so that death takes place in buy cheap xanax online in usa general collapse usually preceded by imconsdousness.the action of aconitine on the medulla consists of a verytransient stimulation of the vasomotor and respiratory centres,followed by depression, so that a slight temporary increasein the force of the respirations and of the blood pressure is followed by a decrease.the heart, at first quickened for a short time, due to stimulation of the motor ganglia, is soon slowed by stimulation of thevagus and by depression of the ganglia. Quality planningthe process of building quality into the development or productionprocesses and into the product.

cheap xanax 1mg in the uk online


Inordinary circumstances, therefore, they have no need to protect thefixed alkalies, and are unprovided with any mechanism for this purpose.when an excess of acid is absorbed, they neutralize it by means of thefixed alkali of the tissues and blood, and thus lessen the available alkaliof the blood, which becomes unable to carry so much buy cheap xanax online in usa carbonic acidfrom the tissues to the lungs. The onlypharmacodynamic effect was a small (3.5bpm) increase in heart rate. Although neuroprotective properties have not beenshown for benzodiazepines, these drugs are potent anticonvulsantsused in the treatment of status epilepticus, alcohol withdrawal,and local anesthetic- induced buy cheap xanax online in usa seizures. Denver airport-i'm in alaska at the moment and am headed to yukon, bc, vancouver, seattle and glacier np over the next two weeks. For nonclinical toxicol-ogy studies emulsion formulations can be selected based on the is zolpidem controlled substance solubility of the active ingredient in lipids and surfactant solutions. These differences are not considered clinically significant [see use in specific populations]. This drug may be purchase alprazolam in mexico degraded by carbon dioxideabsorbents buy cheap xanax online in usa in anesthesia machines to form a nephrotoxic vinyl ethercompound termed œcompound which, in high concentrations,has caused proximal tubular necrosis buy cheap xanax online in usa in rats. Photo-phobia and clonic spasms have been observed in some dogs. Quinine applied still laterprevents or delays the division of the ovum through its effects bothon the nucleus and on the general protoplasm of the cell.the individual cells of more complex organisms are affected in thesame way as these more simple ones. After thyroid feeding the liver buy cheap xanax online in usa isfound to contain only traces of glycogen owing to an inhibition of theglycogenic function, and this may buy cheap xanax online in usa contribute to the increased elimi-nation of nitrogen in the urine (cramer and krause).the thyroid extract loses its therapeutic efficacy if it is completelydigested by xanax safe the pancreatic juice. For patientswith severe renal impairment 10mg is the maximum recommended dose. It is recommended that there be at least 10 days’ treatment forany infection caused bystreptococcus pyogenesto prevent the occurrence of acute rheumatic fever.h. Acyclovir does not cure genital herpes, nor does it protect the user from infecting others with the virus. The rate is need to buy xanax influenced by buy cheap ativan 2mg with american express temperature, radiation, and thepresence of a catalyst. After the hypodermic injection of 1-2 grs. For a typical gelatin,10 percent solutions acquire yield values and begin to gel atabout buy cheap xanax online in usa 25°c, 20 percent solutions gel at buy cheap xanax online in usa about 30°c, and 30 percent solutions gel at about 32°c. Implications for the differentiation between organic and psychogenic impotence. Thus, the same typeof filter should be used for preparing the stability samples aswill be used to prepare the production-size batches.for dry-packaged formulations reconstituted prior to use, thevisual appearance should be observed on both the original drymaterial and on the reconstituted preparation. Prevention of explicit memory (awareness) hasspurred the development of monitors such as the bispectralindex, electroencephalogram, and entropy monitor of auditoryevoked potentials to recognize inadequate planes of anesthesia.consciousnessthe buy cheap xanax online in usa ability of anesthetic drugs to abolish consciousness requiresaction at anatomic locations responsible for the formation ofhuman consciousness. Tendinitis or tendon rupture can involve the achilles, hand, shoulder, or other tendon sites and can occur during or after completion of therapy; cases occurring up to several months buy cheap xanax online in usa after fluoroquinolone treatment have been reported. Inothers delirium and hallucinations of sight and hearing have occurred,these being more frequently seen in chronic alcoholic patients and incases of diabetes than under other where to purchase alprazolam 2mg with visa conditions. Atsteady state, a 500 mg oral dose of ciprofloxacin results in peaksputum concentrations of 1.86|xg/g in patients with cf (lebelet al., 1986). buy cheap xanax online in usa buy cheap xanax tablets there are often found in a plant several distinctbodies belonging to this series, and these may again be accompaniedby others which buy cheap xanax online in usa induce the same symptoms as picrotoxin or saponin.digitalis has been more carefully examined from the chemical pointof view than buy cheap xanax online in usa the other plants, but even its active principles are stillonly partially known, and the subject is yet in an unsatisfactory state;for the amount and character of the active constituents seem to varynot only in different seasons and in plants grown in different soils, butalso in cheapest generic alprazolam 1.5mg online with visa different parts of the same plant. Whereas the cardiac systolic diagnostics in ventricular assist device patients from pump parameters have been investigated by several groups, the diastolic behavior has been barely discussed. However, because of the economic investmentrequired and the need to buy cheap xanax online in usa efficiently access and integrate multipletechnologies, most new drugs are then developed in pharmaceuti-cal companies. In24 hours. The treatment may be repeated if the dropsyreturns.calomel has been used buy cheap xanax online in usa externally as a dusting powder for syphilitic condylomata, as a slight irritant to the cornea, and as an ointment in pruritus andother skin diseases.hydrargyrum cum creta (u.), mercury with chalk, graypowder, is formed by rubbing up metallic mercury with chalk and honey(u.) until the mercury is divided into very fine globules, each encased inchalk. This requires expertise fromsynthetic, analytical and process chemistry. Buy cheap xanax overnight when clearance is related to age, it isfound that clearance of this drug does not change with age. Effects on blood pressure and heart rate whenis combined with nitrates:astudy was conducted in which the blood pressure and heart rateresponse to 0.4 mgnitroglycerin (ntg)sublingually was evaluated in 18 healthy subjects following pretreatmentwith 20 mg at various times before ntg administration. The secretion of saliva in the normal animalseems to occur only when impulses reach the gland cells by one of twopaths — through the chorda tympani, or through the cervical sympatheticfibres. Almost the same condition is observed in frogs whose lungsbecome greatly distended with air on account of a spasmodicclosiure of the glottis.the mother substance of cicutoxin or cicuta virosa, hasgiven rise to cases of poisoning by being conf oimded with flavoringherbs, or eaten by children. Criterion-related validity of a phallometric test for paraphilic rape and sadism. Recent ad-vances in drug discovery, primarily in the field of biotechnologyand in the required controls over manufacturing processes, arepresenting new challenges to the control of quality and to thesystems that operate internally in the industry. The blood changes are not the cause of death in poisoning, as wasformerly supposed, but the direct action of the sulphides on the central nervoussystem.sulphides absorbed into the blood are rapidly oxidized, and are excretedin the urine in the form of sulphates buy xanax online forum and of organic sulphur compounds ofunknown constitution. The former stimulates buy cheap xanax online in usa the medullary centres, butsubsequently paralyzes them, while caffeine, even in comparativelylarge quantities, does not seem to have a depressant action in man.atropine at one time had some reputation in the treatment of epi-lepsy. The time to development of the first skin tumors was 50 weeks in mice treated concomitantly with uva and ciprofloxacin (mouse dose approximately equal to the maximum recommended daily human buy cheap xanax online in usa dose of 1000 mg based upon body surface area), as opposed to 34 weeks when animals were buy cheap xanax online in usa treated with both uva and vehicle. In others it issaid to be excreted in the urine unchanged.

order xanax 2mg in canada

This procedure initself has been followed by complete anaesthesia and it undoubtedly decreases enormously the amoimt of the volatile anaestheticwhich buy cheap xanax online in usa has to be employed. (60 grs.sodii citrotartras effervescens (b.) 60-120 grs.these two powders contain bicarbonate of sodium and citric and tartaricacids and effervesce when put in water.acetate and citrate of potassium have been largely used as diuretics and inthe treatment of gout and rheumatism. In the usa, this sectionis known as thecmc section and contains a similar data package as in theeu. When buy cheap xanax online in usa a moleculeis found to bind to a welldefined target that is known to be functional in pathways that lead to disease, the identified molecule may potentially be developed into a drug to treat the disease. The latter groupcontains more iron than the control group fed on ironfree food, and ingeneral presents a more healthy and normal appearance.finally, iron has been followed in its course through the tissuesby histological methods, reagents being used which color most forms ofiron, but leave the haemoglobin unaffected. The colics may be excruciating. Secretary of agriculture tom vilsac, cdc director thomas frieden, and fda commissioner margaret hamburg highlighted the work of their cheap xanax 2mg online india respective agencies in addressing nutrition and food safety issues. Once a week. These mechanisms (discussed previouslyunder signaling mechanisms drug actions) may contribute totwo clinically important phenomena: charcoal given in a state ofsuspension to animals is said to have been found in the epithelial cells of theintestine buy cheap xanax online in usa and even in the bloodvessels, but does not have any effect attribu-table to its absorption in man. Shooting pains along the nerves or in thejoints are sometimes complained of, circumscribed areas of partialansesthesia, amblyopia, anosmia or deafness have been described, andin some cases localized paralysis of the muscles of the arm or buy cheap xanax online in usa buy cheap xanax online in usa leg hasbeen induced.the symptoms of mercurial poisoning, both acute buy xanax charlotte and chronic, inanimals, resemble those in man so closely that it is unnecessary todescribe them further.40626 the heavy metalsaction. 69).mineral waters containing large quantities of carbonic acid in solution areoften recommended as baths in various chronic diseases, such as rheumatism.the effects may be due to the carbonic acid in part, but these waters alsocontain salts in solution.solid carbonic acid (carbonic acid snow) has been applied as an irritant invarious external conditions (page 79) and buy cheap xanax online in usa has also been used to induce localanaesthesia by cold (page 71).ever since the discovery of the relation of oxygen to the respiration, attemptshave been made to use it in therapeutics, by inhaling the gas pure or mixedwith air, or by spending a certain time each day in chambers of compressedair. This interchangebetween the blood and where to buy alprazolam 1mg online legit lymph is continued, because as the salt is ex-creted by the kidneys and other excretory glands, a continual variationin the osmotic pressure of both blood and lymph occurs.the xanax anxiety details buy cheap xanax online in usa of the changes between the blood and lymph under theaction of salt and water are still obscure, but there is no question thatthe absorption of either of these leads to an augmentation of the normalexchange of these fluids. The thiosulphate isapparently oxidized with greater difficulty, for walko found 30-50 per cent,eliminated by the kidneys unaltered.much larger quantities are required to poison animals when given by themouth than when injected subcutaneously, because the salt is changed to theharmless sulphate before it reaches the blood. It is re-ported as an amount per volume measurement (e.,microgram/milliliter (μg/ml), unit/ml, or gram/100 ml). In comparing the advantages and drawbacks of the variouslocal anaesthetics, the points to be examined are the general toxicityon absorption, the power of inducing local anaesthesia, and the extentto which the paralysis of the nerve ends is preceded by irritation and isattended by injury to other cells in the neighborhood. The anaesthesiawith ether or chloroform is usually preceded, if not by morphineand scopolamine, by the use of some much more buy cheap xanax online in usa rapidly actingvolatile anaesthetic, as nitrous oxide, ethyl chloride, etc. Inmany cases, however, a short stage of excitement with giddiness, un-certain movements and difficult and indistinct speech buy cheap xanax online in usa precedes sleep,and occasionally symptoms exactly resembling those produced byatropine follow the administration of hyoscine, especially if large dosesare employed. Sleeplessness,tremors and occasionally convulsions, hallucinations, insanity anddelirium have been noted after long abuse, along with indefinite dis-turbances of sensation and motion. With proper medical treatment and buy cheap xanax online in usa specific exercises, most men can perform as they wish. 02 grains).aspidosperma or quebracho is the bark aspidosperma quebracho, atree growing in argentine and chili. The first group consists of drugs whose characteristic action is a depression of the brain.pharmacology.part i.group of ether and chloral.this group contains a series of drugs whose chief action is theproduction of narcosis. The vessels of the cat and dog perfused with ringer's solutioncontract under ergamine, thus reversing their behavior in the intactanimal. Permanganate of potassium solution,one per mille, has been recently advised to oxidize the phosphorus,while peroxide of hydrogen solution is of less value. With beta blocker and sex buy cheap xanax online in usa drugs such as amyl nitrate. These may just cause the drug buy cheap xanax tablets product notto where to buy alprazolam 1.5mg online ireland appear pharmaceutically elegant want to buy alprazolam in thailand or may be an artifact of an-other physical or chemical stability failure.in this treatment, physical and chemical stability are dis-cussed along with those dosage form properties that can bemeasured and are useful in predicting shelf life. Theanimal lies buy cheap xanax online in usa in an extended and tense condition throughout, and passes intocomplete buy cheap xanax online in usa opisthotonos on being touched.sulphides injected intravenously in mammals induce violent convulsions,which seem to be of cerebral origin, for they do not occur in the hind limbswhen the spinal cord is cut. An instinct that is second only to the survival instinct. The pulse alprazolam prescription in italy may besomewhat accelerated at first, but is weak, and later becomes slow andirregular. Dose: lupulinic add. Depressive effect upon the circulation and destruction buy cheap xanax online in usa of the red blood corpuscles,materia medica.fel bovis purificatum (u.), fel bovinum pxirificatum (b.), buy cheap xanax online in usa isforaied from the fresh bile by the addition of alcohol, filtration and evaporation to a pasty consistency. The effects of testosterone administration and visual erotic stimuli on nocturnal penile tumescence in normal men. A few clinical studies in diabeticpatients indicate no apparent impairment of drug metabolism,although impairment has been noted in diabetic rats. Attention to heterosexual buy cheap xanax online in usa imagery as eliciting stimuli for autonomic sexual arousal in males. From the standpoint of the surface,protein adsorption appears to be maximized when the electrical charge of the surface is opposite that of the protein or whenthe surface is extremely hydrophobic. Use of &x2018;sensate focus&x2019; techniques may be advised, encouraging the man to engage in various forms of pleasurable touching and stimulation without obligation to attain an erection and attempt penetrative intercourse. The selected precursorions are broken down by collisionally induced dissociation (cid) with areagent gas such as argon to form the so-called product ions. After 7 days, doxazosin was initiated at 1 mg and titrated up to 4 mg daily over the last 21 days of each period (7 days on 1 mg; 7 days of 2 mg; 7 days where to buy xanax 1mg online no prescription of 4 mg buy cheap xanax online in usa doxazosin). The liniment is used as a rubefacient in bruisesand in other similar conditions. Propecia can increase the number of hairs on the scalp and even fill in thin or balding areas of scalp. My hairline has not receded at all and i was told i have a buy cheap xanax online in usa juvenile hairline. Buy cheap xanax online in usa the only difference from the ed in the episode "every which way but ed" is that ed has a bow on his head, he is a baby, and he is naked. Although everyone theoretically recognizes that impotence is a order alprazolam washington shared problem, for the purposes of an introductory conversation with your partner, you must be willing to take responsibility for your needs, desires and feelings. Similar toother intravenous induction agents, midazolams effect on sys-temic blood pressure is exaggerated in hypovolemic patients. The psychometric properties of buy cheap xanax online in usa the buy cheap xanax online in usa penile tumescence assessment of child molesters.

Categorised in:

This post was written by

Leave a Reply

Your email address will not be published. Required fields are marked *