Cheap zolpiem online with visa - 100% Delivery GuaranteeOctober 5, 2020 7:31 pm Leave your thoughts
Cheap zolpiem online with visalike it View all 1264 reviews $0.32 - $3.84 per pill
order zolpidem 10mg in australia
Imatinibis effective for treating chronic myelogenous cheap zolpiem online with visa leukemia, which iscaused by a chromosomal translocation event that produces anactive bcr/abl fusion protein in hematopoietic cells. A case of cardol poisoning isindistinguishable from one of poison ivy.summary of group actioh.— irritation of the skin at theplace of application and also of the kidneys where excreted. Edd cheap zolpiem online with visa n eddy are three best friends dealing with the mysteries of growing up and trying to get jawbreakers while living in a cul-de-sac full of friends who range from endearingly quirky to downright weird. The second parameter of importance is the measurement of thelength of time necessary to achieve the maximum concentrationafter drug administration. They have also been employedto prevent hemorrhage during surgical operations on the nose andthroat.144 organotherapy.their employment as a stimulant to the circulation in shock isobjectionable on account of the very fleeting action of the prin«ciple.suprarenal extracts have been used, although with little benefit, in cheap zolpiem online with visa the treatment cheap zolpiem online with visa of addison's disease, a sickness attended withdestruction of the suprarenal glands.glandukb suprarenales siccas (u.)i cleaned, dried and powderedglands of cheap zolpiem online with visa sheep and ox. It may be sufficient cheapest generic zolpiem online legally from canada to state that if the ordinarypreparations of iron acted only by binding the sulphides of the intestine, variousother metals would be equally efficient cheap zolpiem online with visa in chlorosis; iron would not be beneficial injected hypodermically, and iron sulphide given so as to escape the action of thegastric juice would be equally useless. In 100 c. The following web browsers, with the exception of safari, are supported for these applications on ms windows xp and 2000. Always follow your doctor's instructions and the directions on your prescription label when taking Acyclovir. Dose as an emetic, 0., 510 grs.therapeutic usea. These cheap zolpiem online with visa events, whichmay be accompanied by tinnitus and dizziness, have been reported in temporal association to theintake of pde5 inhibitors, including tablet. This monograph serves as a basis for the early development team to build the nonclinicaltesting strategy necessary to progress the drug candidate to clinical testing. The mean baseline ef domain scores were 13, 13, 13, 14 for the 5 mg, 10 mg, 20 mg and placebo groups, respectively. The active ingredient in is called tadalafil. — the changes in the heart and vessels are reflectedin the blood-pressure, and it is possible that an additional factor maybe involved in the action of some of the glucosides on the vasomotorcentre.in man therapeutic doses of digitalis have not been found to causeany appreciable change in the arterial tension; but this statement mustbe qualified by the addition, that in those cases cheap zolpiem online with visa in which digitalis ismost beneficial, can i buy ambien at walmart in puerto vallarta the blood-pressure cannot be satisfactorily determined.in animals, however, quantities of digitalis which are sufficient ambien prescription stolen toaffect the heart do not increase the blood-pressure appreciably. — agaricin is used in the night sweats of phthisis and othersimilar conditions and is is ativan a narcotic drug generally given in pill form in doses of 5-60mgs. Occasionally, the dreams are of a cheap zolpiem online with visa disagreeable character and the patient awakes with great depression, nausea andvomiting as may occur after taking morphine. This action can be seen on imicellularorganisms just as with chloroform, which fact makes both thesesubstances antiseptics.alcohol, however, is much weaker in its antiseptic power thanchloroform, as many bacteria may grow abimdantly in a 4 cheap zolpiem online with visa percent, solution. The axisfrom this cell runs to the secretory epithelium. Colloid mercury (hyrgol) hasbeen injected intramuscularly, but has no advantage over the older preparations.several organic mercury combinations in which the metal is attached directlyto the carbon have been formed, but have not yet proved superior to the olderforms in practice.iron differs from the other heavy metals in being essential to thelife of many, perhaps all, forms buy cheap ambien 10mg online no prescription of protoplasm. SIN Number 653-08 is the identification number for providing Office Moving Services for the federal government and for those agencies authorized to use the GSA price schedules. Ergaminediffers from the other bases in acting not on the nerve junctions, buton the unstriated muscle cells directly, and cheap zolpiem online with visa its action varies consider-ably in different species of animals cheap zolpiem online with visa and even in different organs of thesame animal. Used locally in to yi per cent, solution to quiet pain, in 3to 6 per cent, solution to allow of surgical operation or examination by instruments. Variability of stimulus effect in the course cheap zolpiem online with visa of phallometric testing. cheap zolpiem online with visa and other pde5 inhibitors or treatments for erectile dysfunction have not been studied. The reduction of the temperature by the antipyretics lastsonly as long as the drug is present in sufficient quantity in the body,and accordingly as soon as sufficient has been excreted, the intoxicationof the regulating cheap zolpiem online with visa mechanism begins again, and the temperature soonrises to its former height. From the standpoint ofthe protein, cheap zolpiem online with visa the extent of adsorption depends on the molecularweight, the number of hydrophobic side chains, and the relativedistribution of cationic and anionic side chains. The time to development of the first skin tumors was 50 weeks in mice treated concomitantly with uva and ciprofloxacin (mouse dose approximately equal to the maximum recommended daily human dose of 1000 mg based upon body surface area), as opposed to 34 weeks when animals were cheap zolpiem online with visa treated with both uva and vehicle. Qa establishes systems for ensuringthe quality of the product. Direct evidence for molecular orientation hasbeen obtained from studies dealing with the spreading on water of insoluble polar substances containing long hydrocarbonchains, such as fatty acids.in the late 19th century pockels and rayleigh showed thata very small amount of olive or castor oil, when placed on thesurface of water, spreads out, as discussed above. It now becomes important to look at some of thespecific types of surfactants available and to see what cheap zolpiem online with visa structuralfeatures are required for different pharmaceutical applications.the classification of surfactants is quite buy cheap ambien online india arbitrary, cheap zolpiem online with visa buy generic ambien tablets online but onebased on chemical structure appears best as a means of introducing the topic. Ekspert mekanisme for oprindelige folks rettigheder holder i disse dage deres andet arlige mode i fn bygningen i geneve. As a result, water soluble preservatives are more effective, because the concentration of theunbound preservative in the aqueous phase assumes a greatdeal of importance in inhibiting the microbial growth. Some formsof intermission of the pulse are due to unusual activity of the inhibitoryapparatus, and these may be remedied by atropine; but this inter-mission possesses little importance, and seems to require no therapeutictreatment. The mean subject age in this studywas 66.4 years.twenty-five subjects were screened. Cross-study comparisons certainly ambien 10mg best price cannot be used to make decisionsor estimate differences in drug products with the generally ac-ceptable sensitivity of difference detection of 20% or less. The east indians claim, that under itsinfluence they are thrown into a sleep accompanied by the mostdelicious erotic dreams, but the caucasians experience only asa rule a general feeling of comfort and wellbeing and rarelydelusions. Depending ontheir severity, these conditions may significantly impair hepaticdrug-metabolizing enzymes, particularly microsomal oxidases,and thereby markedly affect drug elimination. Precaution should be taken in regard to pregnant women handling propecia tablets. The time of dosing (morning versus evening) had no clinically relevant effectson the rate and extent ofabsorption.renal insufficiencyin clinical pharmacology studies using single-dose tadalafil (5to 20 mg), tadalafil exposure (auc)approximately doubled in subjects with mild (creatinine clearance 51 to 80 ml/min) or moderate(creatinine clearance 31 to 50ml/min) renal impairment and in subjects with end-stage renal diseaseon dialysis.haemodialysis contributes negligibly to tadalafil elimination.27hepatic insufficiencytadalafil exposure (auc) in subjects with mild and moderate hepatic impairment (child-pugh classa cheap zolpiem online with visa and b) is comparable to exposure in healthy subjects when a dose of 10 mg is administered. In man the cheap zolpiem online with visa stimulation of the special sensesand the medulla precedes that of the cord so that increased reflexesand convulsions do not occur while these functions are much increased, if the dose is not too large.strychnine does not cheap zolpiem online with visa stimulate the heart muscle , but slowsthe rhythm of this organ by stimulation of the vagus. The effect of simple least-squares analysis of thistype of data is to force the arrhenius equation through the lowtemperature data and essentially ignore the high-temperatureinformation. In the eu, a qualified pharmacist whois appointed by the applicant or holder of the maa is responsible for thequality of the active ingredient and drug product under development or onthe marketplace. The sum of all ions produced in the mass spectrumof every molecule that exits the gas chromatograph cheap zolpiem online with visa yields a total ion chro-matogram that is used for quantitative analysis. The actionof digitalis, strbphanthus, and squills differs very little when they aregiven in equivalent doses; tincture of digitalis on the whole is the mostreliable.the so-called pure principles should not be given by the mouth;strophanthin, the only one of them recognized by cheap zolpiem online legit the pharmacopoeia,undergoes decomposition in the alimentary tract, especially when givenin pure form. Suspensions offer an alternativeoral dosage form for patients who cannot swallow a tablet orcapsule such as pediatric and geriatric patients. Some of the iodide doesnot appear in the urine, however, and its fate in the body has not beenvery clearly traced. This may occur when thereis not sufficient time for the sponsor to follow the normal regulatoryprocess or when patients do cheap zolpiem online with visa not meet the inclusion criteria as statedin the clinical protocol, or side effects of ambien when purchase generic xanax 1.5mg in singapore an approved clinical protocol is notavailable; a treatment ind is used for experimental drugs that show great promisein clinical testing for order zolpidem 10mg in london serious or immediately lifethreatening conditionswhile the definitive clinical results are not available yet or the fdareview is still underway.there are two categories of inds, i. Containers of type cheap zolpiem online with visa i borosilicateglass are generally used for preparations that are intended forparenteral administration, although type ii treated soda-limeglass may be used where stability data demonstrates its suit-ability. Be duein part to ambien prescription age the menstruum, but not entirely, for sternberg observed arelapse in a case of osteomalacia when pure cod-liver oil was substi-tuted for the phosphorated oil. On account of their excretion incombination with glycuronic add by the urine, they may givethe fehling reduction and cheap zolpiem online with visa thus simulate buy ambien 10mg in canada the presence of sugar.by virtue of their partial excretion through the bronchialmucous membranes, they stimulate its secretion and act also inthis place as disinfectants.the' presence of albumin may be shammed in the nitric acidtest by the resins present in the crude preparation of cubeb andcopaiba, because they give rise to a precipitate. Such decarboxylationswill occur in the following antibiotics: cheap zolpiem online with visa.
buy cheap ambien 10mg in the uk online
(3 gr.) doses thrice a day for 24 days, and is stoppedas soon as the diuresis sets in. Some social and psychological aspects of organic sexual dysfunction in men. For example, drugs such as cisapride, grepafloxacin and terfenadine were removed from the market because of cardiovascular side effectsand bromfenac and troglitazone because of hepatotoxicity. It was formerly believed that even the compounds with thearomatic acids were devoid of this action unless the acid possessed a hydroxylgroup, but this general statement has been shown to be erroneous by gottlieb'swork. The primary stimulation of the respiratory and vasomotor centre in the medulla brings about an increase in the forceof respirations and a rise of blood pressure. But even in the mostfavorable circumstances little of the metal is absorbed, and in acutepoisoning the symptoms arise from the local irritation and corrosionand only to a smaller extent from the general action of the metal.if the absorption of the metals is slow, their excretion progresseseven more gradually, and cheap zolpiem online with visa repeated qri m j n jq+io+irm \ a +h p j r ap -rnmulation in the tissues cheap zolpiem online with visa and thus to intoxication . The symptoms show certain analogies with those inducedadrenaline 365by nicotine, but the latter affects a wider can i buy xanax uk area from its involving thecranial and pelvic autonomic nerves as well as those of the true sym-pathetic. The sweat glandsand the ceruminous glands cheap zolpiem online with visa of the ears are likewise roused to unwontedfiq. They also shotdd be given ior 2 hours before sleep is desired as their action is much slowerthan that of chloral. Least squares (ls) mean change in 6mwd at 48weeks was -51.0 meters (m) inthe placebo group, compared with -64.7 m in the tadalafil 0.3mg/kg group (p= 0.307)and -59.1 m inthe tadalafil 0.6mg/kg group (p= 0.538). However, oral tablets containing a phospho-diesterase inhibitor, sildenifil, (trade name) are nearly as effective and have become the first line treatment throughout the world. Fats and oils must be avoided, as they tend todissolve the poison and promote its absorption. I can't say that i was disappointed in the results we got from propecia (finasteride). The correlation between intracavernosal pressure and cavernosal blood oxygenation. Different cell types expressdifferent accessory proteins, which interact with steroid receptorsand change the functional effects of drug-receptor interaction. For theaction of nicotine on the muscles is opposed by curara, not only innormal muscles, but also in those in which the nerves and nerve-endingshave degenerated through cheap zolpiem online with visa section. Much of that information which applies to the man applies equally to the woman. ambien 6.25 and others as many as 300 or even 500 units.serum antidiphthericum (u.), antidiphtheritic serum, or diph-theria antitoxin, the serum of a horse immunized by the injection of diphtheriatoxin, kept in sealed glass tubes in the dark cheap zolpiem online with visa and at a low temperature. Roadway, parking area, playground, airport runway, etc. This trans-udation of fluid is certainly in accord with the watery character of thestools in arsenic poisoning, but buy sleep aid ambien the explanation does not seem entirelysatisfactory, for it fails to account for the fatty infiltration and thecloudy swelling of the epithelium, which are in some cases the onlylesions found here. Among the major drugs discovered and/or developed in the united cheap zolpiem online with visa states during this period were in-sulin, sulfonamides, penicillin and broad-spectrum antibiotics,cortisone and other steroid compounds, isoniazid, diuretics,and tranquilizers (now commonly referred to as anxiolyticsor antipsychotics). Little patuxent parkway, suite 485, columbia, md 21044-3502. Install the impatient memory card in the as of the's instruction a little manual as with all right. Butmercury acts when no bile reaches the intestine and the stools are ofthe same greenish color, so that it seems likely that this arises fromthe presence of some mercury compound, probably some mixture ofsulphides.the mercurial purges, and in cheap zolpiem online with visa particular calomel, have often beedcredited cheap zolpiem online with visa with increasing the secretion of the bile, but this has beenshown to be incorrect, for stadelmann (in animals) and pfaflf cheap zolpiem online with visa (in man;found that they had no effect on the secretion escaping from a biliaryfistula. When ether is allowed to evaporate upon the skin, it produces cold and local anaesthesia.ether does not affect the cheap zolpiem online with visa contractile power of the parturientuterus in moderate anaesthesia, but in deeper stages, when verygroup of ether and chloral. The center makes use cheap zolpiem online with visa ofœscientific advisory committees to assist in the assessment of a cheap zolpiem online with visa new drug. 7 to 12 years. Culture and susceptibility testing performed periodically cheap zolpiem online with visa during therapy will provide information not only on the therapeutic effect of the antimicrobial agent but also on the possible emergence of bacterial resistance.because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and cheap zolpiem online with visa may not reflect the rates observed in practice. In addition, theytend to render the mucus less tenacious, or may dissolve it completely,and thus improve the condition of the stomach. The saliva under order ambien online canada adrenaline corre-sponds in character with ambien prescription online legal that secreted cheapest generic ambien in korea on stimulation of the cervicalsympathetic trunk, not with that from stimulation of the chordatympani, which is a cranial autonomic nerve and is therefore not sus-ceptible to adrenaline. Further information may be obtainedfrom the bibliography.special techniques and equipment in certain instances willproduce superior emulsions, including rapid cooling, reductionin particle size, or ultrasonic devices. These regions seem to interact asa cortical system via identified pathways, producing a state inwhich humans are awake, aware, and perceiving.our current state of understanding supports the followingframework: erection evoked in male rats by airborne scent from estrous females. Discontinuations due to adverse reactions thought to be drug-related occurred in 0.2% (1/444) of patients in the cipro xr arm and in 0% (0/447) of patients in the control arm. The buy drug zolpidem 10mg in hanoi alcoholic, lactic andbutyric fermentations are retarded, or entirely prevented by quininethrough its effects on the organisms, but it is apparently devoid ofaction on some of the lower forms, for moulds (penicillium) growfreely in solutions of the cheap zolpiem online with visa salts; so that the alkaloid seems order ambien 10mg with paypal to have aselective action here, such as is observed also in its effects on the fer-ments of the higher animals. Transienthypoventilation and, in rare cases, a short period of apnea canfollow rapid administration of a large ambien and acid reflux intravenous dose for induc-tion of anesthesia. The mission cheap zolpiem online with visa ofich is cheap zolpiem online with visa to achieve harmonisation among the regulatory guidelines that governthe development and registration of a new drug.
purchase ambien online legitimateThis demonstrates that ambien and acid reflux nitrous oxide has specificnarcotic properties like ether or chloroform and that the anaesthesia produced by it is not due wholly to asphyxia. Such multiple-phase emulsions and their stability havebeen reviewed by eccleston.13emulsions are widely used in pharmacy and medicine, andemulsified materials can possess advantages not observed informulations in other dosage forms. It is in the aqueous phase that micro-organisms tend to grow. Forinstance, when not more than one hundred grammes are givendaily to a cheap zolpiem online with visa man, it is all burnt except two per cent, cheap zolpiem online with visa which is foundin the urine. This isshown by the fact that stimulation of the motor oculi nerve or of thepostganglionic fibres from the ciliary ganglion is without effect. Cheap zolpiem online with visa the trypsinogen of the pancreas may be changedto trypsin by lime cheap zolpiem online with visa salts.the higher organisms, both animals and cheap zolpiem online with visa plants, have thus beenshown to require lime for some of their functions, and it is zolpidem 10mg prescription gp probablynecessary for many others in which its importance has not yet beenrecognized. After the habit is acquired, the sudden withdrawal of the accustomed dose buy generic zolpidem 10mg online legally from canada producesvery disagreeable symptoms, which consist of a cheap zolpiem online with visa craving for thedrug, often, of diarrhoeas, great depression, and even collapse.morphinism, is usually attended by the following s3miptoms;depravity of the mind, general debility, loss of weight and appetite, loss of sexual powers, sleeplessness, eczemas, contractedpupils, diarrhoea alternating with constipation and finally, deathfrom malnutrition.in acute morphine poisoning, the rational treatment consists of emptying the gastrointestinal tract where morphine isexcreted, by repeated stomach washings and by the administration of zolpiem online canada purgatives. Under theseconditions (figure 19-1a) the thread will remain collapsed. Crystal-line salts cheap zolpiem online with visa with a cool saline taste, readily soluble in cheap zolpiem online with visa water.potassii citras effervescens (u.) 4 g. Daily supplement designed to help you be your best at any time, unique combination of clinically proven ingredients, no drugs, no yohimbe, safe natural ingredients for daily use without side effects, satisfaction guaranteed! It is used mainlyinternally as a disinfectant of the gastrointestinal tract.5 to1.(l) chrysarobin series.chrysarobinum (u.), is a yellow powder extracted from cheap zolpiem online with visa goawhich is present as an exudation in the lacunse of the tnmks of the braziliantree andira araroba. Itshould be added that some of purchase ambien online legitimate the sympathetic terminations are notinvolved in the action of adrenaline; the secretory fibres in the sweatglands are not affected for example, although cheap zolpiem online with visa they are of sympatheticorigin. And others as many as 300 or even 500 units.serum antidiphthericum (u.), antidiphtheritic serum, or diph-theria antitoxin, the serum of a horse immunized by the injection of diphtheriatoxin, kept in sealed glass tubes in the dark and at a low temperature. This requires expertise fromsynthetic, analytical and process chemistry. Amiodarone, sotalol)antiarrhythmic medications or those with congenital qt prolongation, should avoid usingrenal insufficiency:in patients with moderate (clcr= 30-50 ml/min) to severe (clcr<30ml/min) renal impairment, the auc of vardenafil was 20 – 30% higher compared to thatobserved in a control group with normal renal function (clcr>80 ml/min) (seeclinicalpharmacology, cheap zolpiem online with visa pharmacokinetics in special populations). Archives should be built and designed to optimally preserve thearchived materials and protect them against fire. It has well marked'narcotic action, but does not decrease the sensation of pain asdoes morphine, resembling more in this respect the narcotics ofthe chloral group. Dose 1-4 g. Ligand and its sister company x-ceptorcontinue today to work on these want to buy zolpiem online legally important drug target families.ligand markets ontak, targretin capsules, targretin gel, andpanretin gel. In solutions of equal osmotic pres-sure with the blood serum the absorption is slower, because here thenatural flow alone is active, while hypertonic solutions are still moreslowly absorbed or may even be increased at first, because the osmoticpressure acts in the opposite direction from the natural flow. Drug discovery is a flexible process, as opposed to drug development,which operates in a highly regulated environment. As a general rule the paralysis cheap zolpiem online with visa is confined to the extremities,but in some cases it has been found to invade the trunk. As the drug is absorbed, increasing concentrations of the drug areobserved in successive samples until the maximum concentra-tion is achieved. In the case of a two-compartmentmodel (e. Its action ambien prescription florida is more easily localized than that ofpotash and on the other hand is more powerful than cheap zolpiem online with visa the metallic salts, suchas silver nitrate and zinc chloride. Thesecond major formulation development stage occurs to supportphase ii clinical studies (proof of concept phase). Single 1000 mg doses and multiple 1200 mg or 600 mg doses of azithromycin had little effect on the plasma pharmacokinetics or urinary excretion of zidovudine or its glucuronide metabolite. Your attitude and approach will make a critical difference in encouraging buy generic adipex in mexico a reluctant partner to seek treatment or discuss feelings and options. Phosphatidyl serine (in a ratio of 7:3:1) with 45%of the ciprofloxacin encapsulated (di ninno et al., 1993). Voluntary control of penile tumescence among homosexual and heterosexual subjects. Further information may be obtainedfrom the bibliography.special techniques and equipment in certain instances willproduce superior emulsions, including rapid cooling, reductionin particle size, or ultrasonic devices. Such new drug moleculescan then be further explored for their physicochemical, pharmacokinetic,metabolic and toxicological characteristics. Alypine has therefore noclaims to use in therapeutics.novocaine is about one-third aspoisonous as cocaine, and applied locally acts only on the nerves with-out involving the other tissues and thus produces no irritation or hyper-aemia; it does not constrict the vessels cheap zolpiem online with visa as cocaine does. This chapter has been deliberately keptshort since the emphasis of this book is on drug development and there aremany other textbooks that describe the approaches followed in drug discoveryin cheap zolpiem online with visa greater detail.chapter 3 is meant to set the scene for a more detailed description of drugdevelopment in later chapters and concentrates on general aspects of drugdevelopment such as drug development organisation and teams, the scientificdisciplines involved in drug development (i. Other means of investigation are seldom as non-invasive. Or want to add more dominican (carribean) flavor to your bachata dancing, then these are the workshops for you! The fact is that in 1974 the researcher imperato-mcginley described a group of genetically male children from the village of salinas in the dominican republic who were deficient in the enzyme 5-alpha reductase. In healthy men without ed, yohimbe in some cases appears to increase sexual stamina and prolong erections. Average(u.tinctura opii (u.) cheap zolpiem online with visa or laudanum containing in (u.) 10per cent, and in (b.) much less opiimi.51.5 c. The pupil cheap zolpiem online with visa contractswhen physostigmine is employed either locally or internally, andthis contraction may be lessened by the subsequent application ofatropine, but cheap zolpiem online with visa is not altogether removed except by large quantities.on the other hand, the dilatation of the pupil produced by small quanti-348 substances acting after absorptionties of atropine may be diminished cheap zolpiem online with visa by physostigmine, but the resultingcontraction is much less than that caused by physostogmine appliedto the normal eye. In par-ticular the blood-pressure is seldom increased by this method ofadministration; injected intramuscularly it seems to purchase zolpiem with american express have rather moregeneral effect and the blood-pressure often rises, though not invariably.animals are poisoned by large amounts injected hypodermically,and even smaller quantities induce glycosuria and diuresis. If the dose has been sufficientlylarge, it changes into a deep coma with cyanosis of the mucousmembranes and skin, and the respirations become progressivelyfewer and shallower until they cease entirely. The zolpidem tartrate medication diameter of the inhibition zonewas measured for ciprofloxacin (cip), promoted by the diffusion of theantibiotic contained in the disk.the criteria for the definition of resistance according to each standardwere the following: some feveroccasionally accompanies the eruption and renders the diagnosis fromthe cheap zolpiem online with visa infectious exanthemata even more difficult. Erectile dysfunction is what makes us different from the rest of traditional ed clinics. (1\ grs., 5-15 grs., in powder or pill.
Categorised in: Uncategorized
This post was written by